The Role of Staphylococcal Genotypes in the Clinical Course of Atopic Dermatitis

Abstract

Recently, in the pathogenesis of atopic dermatitis, special attention has been paid to opportunistic skin microorganisms. Research has proven that the cause of the disease is a violation of the differentiation of granular cells of the epidermis due to a mutation in the gene responsible for the synthesis of fillagrin (FLG), which is the main component of the natural moisturizing factor of the skin. But even at the same time, the state of skin microbiotas plays an important role in the manifestation of the pathological process, as well as in the chronic course of dermatosis. The hot and dry climate of Central Asia leaves its mark on the clinical course and state of the skin microbiota in patients with atopic dermatitis.